MultiTEP-Based Vaccines Targeting SARS-CoV-2 Spike Protein IgG Epitopes Elicit Robust Binding Antibody Titers with Limited Virus-Neutralizing Activity.

Within the last two decades, SARS-CoV-2 was the third zoonotic severe acute respiratory betacoronavirus (sarbecovirus) to infect humans, following SARS and MERS. The disruptions caused by the pandemic underscore the need for a universal vaccine against respiratory betacoronaviruses. Our group previously developed the universal platform for vaccine development, MultiTEP, which has been utilized in this study to generate a range of SARS-CoV-2 epitope vaccine candidates.

[The analysis of interaction between lipoproteins and steroid hormones].

Using the methods of ultracentrifugation, gel-filtration and fluorescence quenching, we demonstrated, that plasma lipoproteins bind steroid hormones and can therefore play a role of their active transport form in an organism. High density lipoproteins have revealed the highest affinity to steroids for. It has been found, that protein component of lipoproteins takes part in the formation of lipoprotein-steroid complex.

[Role of tumor-associated macrophages in the regulation of protein biosynthesis in Ehrlich carcinoma cells].

The paper discusses the role of peritoneal macrophages in uptake and metabolic degradation of high-density proteins of lipoproteins in mice with Ehrlich ascites carcinoma. These processes were found to be influenced by cortisol. Distinctions in spectra of endocellular proteins in tumor-associated macrophages and peritoneal ones in intact mice were identified and, in particular, relative to apolipoprotein E level.

[The pharmacodynamics of theophylline (euphylline)].

A single intravenous administration of 2.4%-10.0 euphylline to 35 patients with obstructive affections of the lungs entailed a broncholytic effect in large airways in patients with reversible obstruction under sub-therapeutical theophylline concentrations in the serum.