Publications by authors named "R M Knapek"
Toxic effect of insecticide dimethoate applied to 400 rats for two years in concentrations of 2 to 200 mg/kg fodder was investigated. During the last six months of observation the toxic influence of the larger doses of this preparation was manifested by a higher mortality of the animals. Neither disadvantageous influence upon the maturation of each individual haemopoietic series, nor action inducing pathologic proliferation in the haemopoietic system of rats were found.
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- The study investigated the impact of the fungicide PF-70, containing sulphur, mancozeb, and triadimefon, on the gastric mucosa electrolyte barrier in Wistar rats over 13 weeks.
- Evidence of mucosal lesions, a risk factor for chronic peptic ulcer disease, was assessed by measuring transmural electric potential differences before and after exposure to hydrochloric acid and acetylsalicylic acid.
- Results indicated no overall health changes in the rats, but males showed increased food intake at higher doses, while females experienced body mass loss at the highest dose, with all groups showing decreased electric potential differences, signaling damage to the mucosa.
The results of a chronic 2-years experiment of thiram on Wistar-rats are given. On the basis of clinical, biochemical and pathomorphological investigations a Noel of 5 mg/kg bw were proposed.
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