High-throughput UPLC-ESI/MSMS method for simultaneous measurement of the urinary metabolites of volatile organic compounds and tobacco alkaloids.

Human exposure to volatile organic compounds (VOCs) poses significant health risks, contributing to cardiovascular disease, pulmonary disease, and cancer. Measurement of VOC metabolites (VOCm) in urine by liquid chromatography-mass spectrometry (LC-MS) is a preferred method for VOCm analysis; however, existing methods encounter challenges related to sensitivity, throughput, and analyte coverage. In addition to VOCm, the measurement of tobacco alkaloids (TAm) is critical to account for tobacco use in population-based studies.

Potential of phosphodiesterase 4B inhibition in the treatment of progressive pulmonary fibrosis.

Idiopathic pulmonary fibrosis (IPF) is often regarded as the archetypal progressive fibrosing interstitial lung disease (ILD). The term "progressive pulmonary fibrosis" (PPF) generally describes progressive lung fibrosis in an individual with an ILD other than IPF. Both IPF and PPF are associated with loss of lung function, worsening dyspnea and quality of life, and premature death.

The Green Heart Project: Objectives, Design, and Methods.

The Green Heart Project is a controlled, community-based clinical trial to evaluate the effects of increasing greenery on community health. The study was initiated in 2018 in a low-to-middle-income residential area of nearly 30,000 racially diverse residents in Louisville, KY. Community engagement was maintained throughout the project, with feedback integrated into its design and implementation.

Rate of non-metastatic solid tumor progression following critical illness: a prospective cohort study of UK Biobank participants.

Objective: To determine whether admission to critical care is associated with subsequent disease progression in patients with non-metastatic solid tumors.

Methods: This observational cohort study of UK Biobank participants identified those diagnosed with solid tumors and survived hospitalization. Two cohorts were identified based on critical care admission and new metastatic disease as reported at UK Biobank follow-up visits, or primary or secondary care records were compared.

The association between perceived neighborhood safety and cardiovascular disease risk factors.

Cardiovascular disease (CVD) remains the leading cause of mortality in the U.S. accounting for 1 in 4 deaths each year.