Publications by authors named "R M Johnstone"
Single-nucleotide variants (SNVs) are extremely prevalent in human cancers, although most of these remain clinically unactionable. The programmable RNA nuclease CRISPR-Cas13 has been deployed to specifically target oncogenic RNAs. However, silencing oncogenic SNVs with single-base precision remains extremely challenging due to the intrinsic mismatch tolerance of Cas13.
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- Therapeutic strategies focusing on disrupting dysregulated transcription have shown promise for treating cancers like leukaemias using small molecule inhibitors that target key proteins involved in gene expression.* -
- Research indicates that the effectiveness of these inhibitors is influenced not just by their ability to stop mRNA production, but also by how quickly mRNA is produced and degraded.* -
- Findings suggest that modifying post-transcriptional processes, such as targeting specific proteins, can enhance the effects of transcriptional inhibitors, offering potential new combination therapies for leukaemia.*
Neglected Tropical Diseases (NTDs) are a group of chronic infectious diseases of poverty affecting over one billion people globally. Intersections of NTDs, disability, and mental ill-health are increasingly evidenced but are rarely studied from a mixed-methods perspective. Here, we advance syndemic understandings by further assessing and contextualising the syndemic relationship between NTDs (particularly their associated disability) and mental distress in Liberia.
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