Publications by authors named "R M Grohe"

The hyperglycaemia seen in type 2 diabetes mellitus (DM2) is associated with increased oxidative stress and production of reactive oxygen species, both of which are factors that can provoke DNA damage. Notwithstanding, other factors, including medications and individual susceptibility, can also induce this type of DNA lesion. The objective of this study was, therefore, to investigate the influence of glycaemic control, oral antidiabetic drugs (metformin and glibenclamide) and polymorphisms of the XRCC1 and XRCC3 genes on the frequency of DNA damage in DM2 patients, which was accessed by the cytokinesis-block micronucleus cytome and the comet assays on the ex vivo mitogenically stimulated lymphocytes.

View Article and Find Full Text PDF

Purpose: Superior corneal flattening associated with inferior corneal steepening is a videokeratoscopic topography pattern that usually describes both keratoconus and contact lens induced warpage. To differentiate these two conditions topographically, we analyzed ten different corneal topographic shape variables and found that two distinct conditions were described. Three unique measurements of corneal geometry: shape factor (SF), irregularity (CIM), and apical toricity (TKM) were analyzed and evaluated as an additional method for differentiating these two conditions.

View Article and Find Full Text PDF

Background: Rigid gas permeable (RGP) contact lenses have numerous benefits; however, one of the possible problems of RGP lenses is variable quality that can result in reduced initial comfort and an unsuccessful fit.

Methods: A quality control survey was sent to 200 optometrists, selected at random, to provide information on lens usage, verification, use of reused or modified lenses, use of authorized laboratory, and to evaluate important laboratory characteristics. A total of 86 optometrists responded to the survey.

View Article and Find Full Text PDF

The introduction of fluoro-silicone/acrylate rigid lens materials has provided wearers with benefits that include, among others, enhanced surface wettability. However, several reports have associated these lens materials with lens power, base curve radius and center thickness changes over time, especially with long-term use of an abrasive cleaner. The purpose of this study was to evaluate the effect of abrasive and non-abrasive cleaners on these specific lens parameters.

View Article and Find Full Text PDF