CRISPR/Cas9-driven double modification of grapevine MLO6-7 imparts powdery mildew resistance, while editing of NPR3 augments powdery and downy mildew tolerance.

The implementation of genome editing strategies in grapevine is the easiest way to improve sustainability and resilience while preserving the original genotype. Among others, the Mildew Locus-O (MLO) genes have already been reported as good candidates to develop powdery mildew-immune plants. A never-explored grapevine target is NPR3, a negative regulator of the systemic acquired resistance.

Adherence of Physicians to Local Guideline Recommendations among Patients with COVID-19 in Two Tertiary Public Hospitals in Metro Manila, Philippines: A Rapid Assessment Study.

Objectives: Adherence to clinical practice guidelines (CPG) has been shown to reduce inter-physician practice variation and improve quality of care. This study evaluated guideline adherence of physicians in two tertiary public hospitals to local CPG on COVID-19.

Methods: This was a multicenter, retrospective chart review, rapid assessment method study.

Health-Related Experiences of Transgender and Gender-Diverse Coloradans: A Scoping Review of the Literature.

Background: Extant literature on transgender and gender-diverse (TGD) people living in the United States is centered on bicoastal metropolitan cities. Little is known about the health status and health-related barriers among TGD people living in the middle of the country. Minority Stress Theory (MST) provides a framework for understanding how TGD people experience stressors that shape their health-related experiences.

Repurposing chemotherapy-induced peripheral neuropathy grading.

Background And Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is perceived differently by patients and physicians, complicating its assessment. Current recommendations advocate combining clinical and patient-reported outcomes measures, but this approach can be challenging in patient care. This multicenter European study aims to bridge the gap between patients' perceptions and neurological impairments by aligning both perspectives to improve treatment decision-making.