Publications by authors named "R M Garipov"
Background: Actual Flip angle Imaging (AFI) is a sequence used for B mapping, also embedded in the Variable flip angle with AFI for simultaneous estimation of T , B and equilibrium magnetization.
Purpose: To investigate the design of a preparation module for AFI to allow a fast approach to steady state (SS) without requiring the use of dummy acquisitions.
Methods: The features of a preparation module with a B insensitive adiabatic pulse, spoiler gradients, and a recovery time were studied with simulations and validated via experiments and acquired with different k-space traveling strategies.
The experimental solubility data of polyvinyl chloride (PVC) and high-pressure polyethylene (HPPE) in organic solvents (toluene, dichloromethane, and chloroform) at temperatures ranging from 308.15 to 373.15 K at atmospheric pressure are reported in the present paper.
View Article and Find Full Text PDFThe availability of preclinical simultaneous PET/MR imaging systems has been increasing in recent years. Therefore, this technique is progressively moving from the hands of pure physicists towards those of scientists more involved in pharmacology and biology. Unfortunately, these combined scanners can be prone to artefacts and deviation of their characteristics under the influence of external factors or mutual interference between subsystems.
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- The study focuses on creating a new rapid imaging technique using hyperpolarized carbon MRI to capture real-time metabolic reactions in small areas of the body during medical imaging.
- A specialized pulse sequence was developed, tested in laboratory settings, and later applied to live rats to track metabolic changes related to two carbon compounds, achieving impressive spatial and temporal resolution.
- Results showed that this new imaging strategy effectively differentiated metabolic activity across organs, with certain metabolic processes, like the conversion of pyruvate to lactate, prominent in the liver and others in the kidneys and heart, enabling better understanding of metabolic pathways.
A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B metabolite necessary for >140 biotransformations was mapped by CEST-MRI and in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.
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