The Single Leg Bridge Test Does Not Measure Isolated Hamstring Endurance in Healthy Men.

Background: The Single Leg Bridge Test (SLBT) is commonly described as a measure of 'hamstring endurance'. Nevertheless, the relationship between the SLBT score and isolated hamstring endurance remains uncertain.

Purpose: This study aimed to investigate the correlation between SLBT scores and isolated hamstring endurance in healthy men.

Dose, exposure, and treatment regimen of intravenous immunoglobulin G in multifocal motor neuropathy.

Introduction: Intravenous immunoglobulin (IVIG) is the only approved treatment for multifocal motor neuropathy (MMN), a rare, chronic, immune-mediated demyelinating neuropathy. There is a significant gap in understanding of the role of serum immunoglobulin G (IgG) levels in the efficacy of IVIG in affected patients. We aimed to characterize the interplay between dose and exposure of IVIG and the effects of patient factors on individual variabilities.

Perspectives and involvement of children and adolescents during the decision-making process of their Covid-19 vaccination.

Objective: This study aims to understand the perspectives of young people towards their Covid-19 vaccination and their involvement in the decision-making process.

Methods: Semi-structured interviews were conducted with 25 children and adolescents (aged 8-19 years), who attended a school in Germany during the pandemic. Interviews were explored with structured and evaluative content-analysis.

Cannabidiol for treatment of Irritability and Aggressive Behavior in Children and Adolescents with ASD: Background and Methods of the CAnnabidiol Study in Children with Autism Spectrum DisordEr (CASCADE) Study.

Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder commonly associated with behavioral challenges. There are few evidence based pharmacological interventions available for the treatment of behavioral symptoms associated with ASD. Cannabidiol (CBD), the non-psychoactive component of cannabis, has potential neuroprotective, antiepileptic, anxiolytic, and antipsychotic effects and may be useful in treating the behavioral symptoms of ASD.

Dose-exposure-efficacy response of intravenous immunoglobulin G 10% in multifocal motor neuropathy.

Objective: Multifocal motor neuropathy is a rare chronic immune-mediated neuropathy with impaired grip strength representing a common symptom. While intravenous immunoglobulin G is an effective treatment for the disease, significant variation in treatment response has been observed but not well understood. This analysis characterized dose-exposure-response relationships in multifocal motor neuropathy, using grip strength as a clinical efficacy measure.