Two infA gene mutations independently originated from a mutator genotype in barley.

Cytoplasmic line 2 (CL2) is a chlorophyll mutant that was selected from a plastid mutator genotype in barley. The dynamics of greening and plastid development of CL2 first-leaf blade contrasts with that of monocots. Previous characterizations of CL2 suggested that this mutant has a delay of plastid gene translation during embryogenesis.

Usefulness of a 12-month treatment with finasteride in idiophathic and polycystic ovary syndrome-associated hirsutism.

Objective: Hirsutism is considered as a skin disease due to increased 5 alpha-reductase activity in the pilosebaceous unit and finasteride is a drug that inhibits this enzymatic activity. This study showed the effectiveness of a chronic treatment with a selective 5 alpha-reductase inhibitor, finasteride, in idiopathic and PCOS-associated hirsutism.

Methods: Finasteride was administered orally at a daily dose of 5 mg for a period of 12 months to 20 women with IH and 20 women with PCOS.