Publications by authors named "R M C Mestrom"
Article Synopsis
- - A new system called the thermobrachytherapy (TBT) prototype has been developed to combine interstitial hyperthermia with high-dose-rate brachytherapy (HDR-BT), aiming to improve treatment effectiveness in cancer therapy.
- - The TBT system includes sophisticated components like radiofrequency power delivery and dual-function applicators, and has been tested for efficiency, heating capacity, and temperature regulation through a series of experiments.
- - Results showed that the TBT prototype met necessary requirements, achieving a 50% heating efficiency with a 6°C increase in temperature in 6 minutes, and is ready for further validation testing and potential clinical applications.
Background: Transcranial direct current stimulation (tDCS) is used to modulate neuronal activity, but the exact mechanism of action (MOA) is unclear. This study investigates tDCS-induced modulation of the corticospinal excitability and the underlying MOA. By anesthetizing the scalp before applying tDCS and by stimulating the cheeks, we investigated whether stimulation of peripheral and/or cranial nerves contributes to the effects of tDCS on corticospinal excitability.
View Article and Find Full Text PDFConventional transcranial electric stimulation(tES) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields. Recent advancements in in vivo electric field characterization may enable clinical researchers to derive better relationships between the electric field strength and the clinical results. Subject-specific electric field simulations could lead to improved electrode placement and more efficient treatments.
View Article and Find Full Text PDFIn high-dose-rate brachytherapy (HDR-BT) for prostate cancer treatment, interstitial hyperthermia (IHT) is applied to sensitize the tumor to the radiation (RT) dose, aiming at a more efficient treatment. Simultaneous application of HDR-BT and IHT is anticipated to provide maximum radiosensitization of the tumor. With this rationale, the ThermoBrachyTherapy applicators have been designed and developed, enabling simultaneous irradiation and heating.
View Article and Find Full Text PDFThe combination of interstitial hyperthermia treatment (IHT) with high dose rate brachytherapy (HDR-BT) can improve clinical outcomes since it highly enhances the efficiency of cell kill, especially when applied simultaneously. Therefore, we have developed the ThermoBrachy applicators. To effectively apply optimal targeted IHT, treatment planning is considered essential.
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