G protein-coupled oestrogen receptor regulates branched-chain amino acid metabolism through c-Jun N-terminal kinase.

Branched-chain amino acids (BCAA) are essential requirements for overall protein turnover, signalling and energy balance, and dysregulation of their metabolic pathway has been associated with many pathophysiological events. Despite the importance of BCAA in human health, our understanding of their metabolic regulation is limited. Here, we present evidence that G protein-coupled oestrogen receptor (GPER) activation inhibits the key BCAA metabolic regulatory enzyme branched-chain α-keto acid dehydrogenase complex (BCKDH) by phosphorylating S293.

Impact of Smoking on Recurrence and Angiographic Outcomes After Endovascular Treatment of Intracranial Aneurysms: A Systematic Review and Meta-Analysis.

Background: Cerebral aneurysm recurrence serves as a significant endpoint for assessing the efficacy of various endovascular treatment strategies. The impact of smoking on outcomes such as aneurysm occlusion, recurrence, and recanalization remains unclear due to conflicting evidence.

Purpose: To systematically evaluate the role of smoking in influencing angiographic outcomes following endovascular treatment of intracranial aneurysms.

Doxorubicin-induced phosphorylation of lamin A/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart.

Cardiotoxic effect of Doxorubicin (Dox) limits its clinical application. Previously, we reported that Dox induces phosphorylation of lamin A/C (pS22 lamin A/C), increased nuclear size, damage to the nuclear membrane, and cell death. However, the activation of signalling pathway during this event remains elusive, and it is unclear whether increased phospho-lamin A/C activates the cell death pathway in heart.

Psychometric evaluation and cross-cultural adaptation of the Konkani version of the Oral Health-related Early Childhood Quality of Life (OH-ECQoL) scale.

Context: The oral health-related early childhood quality of life (OH-ECQoL) tool, designed to evaluate how dental issues affect preschoolers' and their family's quality of life (QoL), has been translated and validated in many languages. However, it has not yet been adapted into the Konkani language.

Aim: Cross-cultural adaptation of OH-ECQoL tool for use in the Konkani-speaking population in the state of Goa among primary caregivers of children aged 24-71 months.

Direct Printing of an Electrochemical Device and Its Interface with Paper for Uric Acid Detection in Human Sweat.

Using a laser-scribed (direct printing) technique, we have fabricated an enzymeless, mediatorless, and paper-interfaced electrochemical device (P-LSG) for uric acid detection on a flexible polyimide sheet. Various paper substrates were investigated, and it was found that Whatman filter paper-1 is promising to obtain the best electrochemical signals at the small volume of electrolyte, i.e.