Publications by authors named "R M Bonelli"
Article Synopsis
- The study investigated the genomic characteristics of different serotypes of bacterial isolates (Agona, Braenderup, Muenchen, and Panama) found in surface waters of Chile, Mexico, and Brazil over three years.
- Mexican isolates showed a higher prevalence of antimicrobial resistance (AMR) genes compared to those from Chile and Brazil, with specific patterns of ARG distribution across the different serotypes and countries.
- The research highlights the intricate relationships between the isolates, including gene sharing and clustering patterns that point to surface waters as potential reservoirs for multidrug-resistant bacteria, underscoring the need for ongoing monitoring and research.
Article Synopsis
- Metabolic homeostasis relies on multiple pathways to supply nutrients during fasting and stress, regulated by organs like the liver and kidney.
- Research shows that serine and glycine metabolism is crucial for maintaining retinal amino acids, especially in individuals with macular telangiectasia (MacTel) who have genetic issues affecting SGOC enzymes.
- A mouse model with reduced serine synthesis exhibits faster retinal degeneration due to dietary restrictions, but serine supplementation can reverse retinopathy and neuropathy, suggesting potential therapies for neuro-retinal conditions.
Neisseria gonorrhoeae ST-1901 in Rio de Janeiro from 2006 to 2022: Phylogeny and antimicrobial resistance evolution of a well-succeeded pathogen.
Int J Antimicrob Agents
October 2024
Neisseria gonorrhoeae is a global threat to public health due to the accumulation of antimicrobial resistance mechanisms. ST-1901 is an internationally important sequence type (ST) because of its high incidence and the usual occurrence of chromosomally determined resistance. In this study, we describe the evolution of the ST-1901 and its single locus variants in Rio de Janeiro from 2006 to 2022.
View Article and Find Full Text PDFSurface water ecosystems are intimately intertwined with anthropogenic activities and have significant public health implications as primary sources of irrigation water in agricultural production. Our extensive metagenomic analysis examined 404 surface water samples from four different geological regions in Chile and Brazil, spanning irrigation canals (n = 135), rivers (n = 121), creeks (n = 74), reservoirs (n = 66), and ponds (n = 8). Overall, 50.
View Article and Find Full Text PDFObjective: Abnormal changes in metabolite levels in serum or plasma have been highlighted in several studies in age-related macular degeneration (AMD), the leading cause of irreversible vision loss. Specific changes in lipid profiles are associated with an increased risk of AMD. Metabolites could thus be used to investigate AMD disease mechanisms or incorporated into AMD risk prediction models.
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