The age-related incidence of male genital lichen sclerosus is triphasic.

Background: Male genital lichen sclerosus (MGLSc) is a chronic and acquired inflammatory dermatosis associated with substantial sexual dysfunction and urological morbidity and mortality. The age incidence of MGLSc is held to be biphasic, with a peak in infancy and another in adulthood. A recent review has implied two peaks in adulthood (making it triphasic overall); this triphasicity has been our emergent clinical impression from a voluminous practice.

Observational study of survival outcomes of people referred for 'fast-track' end-of-life care funding in a district general hospital: too little too late?

Background: End-of-life care requires support for people to die where they feel safe and well-cared for. End-of-life care may require funding to support dying outside of hospital. In England, funding is procured through Continuing Healthcare Fast-Track funding, requiring assessment to determine eligibility.

4CMenB sustained vaccine effectiveness against invasive meningococcal B disease and gonorrhoea at three years post programme implementation.

Objectives: To evaluate persistence of vaccine effectiveness (VE) and vaccine impact (VI) on invasive meningococcal B (MenB) disease and gonorrhoea at three years after implementation of a state funded 4CMenB programme for infants, children, adolescents and young people in South Australia.

Methods: VI was assessed using a Poisson or negative binomial regression model, and VE was estimated using screening and case-control methods. Chlamydia controls were used to estimate VE in the primary analysis to control potential confounding effects such as high-risk sexual behaviour associated with sexually transmitted infections.

Effectiveness and impact of the 4CMenB vaccine against invasive serogroup B meningococcal disease and gonorrhoea in an infant, child, and adolescent programme: an observational cohort and case-control study.

Background: A programme of vaccination with the four-component serogroup B meningococcal (4CMenB) vaccine was introduced in South Australia for infants and children aged 0-3 years on Oct 1, 2018, and for senior school students in school years 10 and 11 (aged 15-16 years) and young adults aged 17-20 years on Feb 1, 2019. We aimed to evaluate vaccine effectiveness and impact on serogroup B meningococcal disease and gonorrhoea 2 years after implementation of the programme.

Methods: We did a cohort and case-control study among those targeted by the South Australia 4CMenB vaccination programme.

Long-term dynamics of nitrogen flow in a typical agricultural and pastoral region on the Qinghai-Tibet Plateau and its optimization strategy.

Nitrogen (N) plays a central role in livestock development and food production in agricultural and pastoral regions, while its flow and loss can affect environmental quality, biodiversity and human health. A comprehensive understanding of the sources, patterns and drivers of N flow helps to alleviate its negative effects and promote sustainable management. We developed a county-scale N flow model to quantitatively analyze the N use efficiency (NUE), N losses and their driving forces in the food production and consumption system (FCPS) on the Qinghai-Tibet Plateau (QTP).