Application of -based test systems for the assessment of genotoxic effects of environmental radioactivity of undisturbed mountain soils (Aragats Massif, Armenia).

Plant test systems are a sensitive way to detect the genetic effects of various contaminants in environmental compartments: water, soil and sediments. Biotesting of the genotoxicity of soil samples with various activity concentrations of naturally occurring (Ra, Th, K) and artificial (Cs) radionuclides in soil, from the territory of the Aragats Massif (Armenia) was carried out with the application of the micronucleus (Trad-MСN) and stamen hair mutation (Trad-SHM) bioassays of (clone 02) model test-object in the soil - plant system. Undisturbed soil sampling was performed in the southern slopes of the Aragats Massif, from different altitudes (from 1000 to 3200 m above sea level).

Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities.

Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various cancer hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, and tissue-specific expression. These non-coding RNAs function through mechanisms such as miRNA sponging, interactions with RNA-binding proteins (RBPs), and modulating transcription and splicing.

DNA Damage in Moderate and Severe COVID-19 Cases: Relation to Demographic, Clinical, and Laboratory Parameters.

The ability of the SARS-CoV-2 virus to cause DNA damage in infected humans requires its study as a potential indicator of COVID-19 progression. DNA damage was studied in leukocytes of 65 COVID-19 patients stratified by sex, age, and disease severity in relation to demographic, clinical, and laboratory parameters. In a combined group of COVID-19 patients, DNA damage was shown to be elevated compared to controls (12.

Changes in Telomere Length in Leukocytes and Leukemic Cells after Ultrashort Electron Beam Radiation.

Application of laser-generated electron beams in radiotherapy is a recent development. Accordingly, mechanisms of biological response to radiation damage need to be investigated. In this study, telomere length (TL) as endpoint of genetic damage was analyzed in human blood cells (leukocytes) and K562 leukemic cells irradiated with laser-generated ultrashort electron beam.

The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections.

Cell-free DNA (cfDNA) in human blood serum, urine, and other body fluids recently became a commonly used diagnostic marker associated with various pathologies. This is because cfDNA enables a much higher sensitivity than standard biochemical parameters. The presence of and/or increased level of cfDNA has been reported for various diseases, including viral infections, including COVID-19.