Publications by authors named "R Luerding"
Article Synopsis
- Short-acting anesthetics like propofol allow for quick recovery during awake craniotomy, but they may cause temporary neurocognitive impairment.
- Neurocognitive tests showed significant drops in word fluency and digit span up to 24 hours post-surgery, particularly impacting older patients, suggesting prolonged effects of anesthesia.
- In contrast, patients who underwent awake craniotomies without sedation maintained stable cognitive performance, indicating that sedation may play a crucial role in the observed cognitive deficits.
Background: Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity in adult medulloblastoma patients. Here we investigated the long-term impact of this treatment, focusing on neurocognitive functioning and health-related quality of life (HRQoL).
Methods: Neurocognitive functioning and HRQoL scores over time were determined, and differences between the post-treatment and follow-up assessments were calculated up to 18 months for neurocognition and 60 months for HRQoL.
Background: Medulloblastoma in adult patients is rare, with 0.6 cases per million. Prognosis depends on clinical factors and medulloblastoma entity.
View Article and Find Full Text PDFThe brain undergoes adaptive changes during learning. Spontaneous neural activity has been proposed to play an important role in acquiring new information and/or improve the interaction of task related brain regions. A promising approach is the investigation of resting state functional connectivity (rs-fc) and resting state networks, which rely on the detection of interregional correlations of spontaneous BOLD fluctuations.
View Article and Find Full Text PDFThe concept of cognitive reserve (CR) and its influence on cognitive impairment has attracted increasing interest. One hundred twenty-eight patients with multiple sclerosis (MS) from Southern Germany were evaluated during the years 2000 to 2012. Twenty-seven neuropsychological (NP) tests were applied regarding basic cognitive functions, attention, executive functions, visual perception and construction, memory and learning, problem solving, and language.
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