Publications by authors named "R Luckett"

Objective: To evaluate the impact of ART duration and CD4 count on risk for high grade cervical dysplasia in women with HIV (WWH) compared to women without HIV in the treat-all era with integrase strand inhibitors (INSTIs).

Design: Prospective longitudinal cohort study in Botswana.

Methods: From February 2021 to August 2022, baseline HPV self-sampling was offered to women with and without HIV.

View Article and Find Full Text PDF
Article Synopsis
  • International guidelines suggest stopping cervical screenings at age 50 if two consecutive tests are negative, but many women over 50 in LMICs, like Botswana, haven't had the chance to screen.
  • The study analyzed data from two separate cohorts—one for screening with 2,570 women aged 30+ and another with 1,520 cervical cancer patients—to understand the prevalence of cervical dysplasia and cancer stages by age and HIV status.
  • Results showed similar prevalence rates of cervical intraepithelial neoplasia (CIN) between women aged 30-49 and 50+, regardless of HIV status, indicating no significant differences in disease prevalence across these age groups.
View Article and Find Full Text PDF

A number of challenges hinder artificial intelligence (AI) models from effective clinical translation. Foremost among these challenges is the lack of generalizability, which is defined as the ability of a model to perform well on datasets that have different characteristics from the training data. We recently investigated the development of an AI pipeline on digital images of the cervix, utilizing a multi-heterogeneous dataset of 9,462 women (17,013 images) and a multi-stage model selection and optimization approach, to generate a diagnostic classifier able to classify images of the cervix into "normal", "indeterminate" and "precancer/cancer" (denoted as "precancer+") categories.

View Article and Find Full Text PDF

SARS-CoV-2 infection during pregnancy was associated with maternal mortality and adverse birth outcomes in the pre-Omicron era, including a stillbirth rate of 5.6% in Botswana. We re-evaluated these outcomes in the Tsepamo Study during the Omicron era.

View Article and Find Full Text PDF

Objective: The World Health Organization (WHO) recommended addition of local anesthetic to reduce the intense pain of intramuscular injection of 50% Magnesium Sulphate (MgSO) salt solution has been found to be ineffective. We tested whether giving the local anesthetic 5 min before the MgSO injection would reduce pain.

Methods: We conducted a prospective cross-over trial where each participant with pre-eclampsia or eclampsia received sequential and mixed injection methods in random sequence during sequential MgSO administrations.

View Article and Find Full Text PDF