Publications by authors named "R Lopez-Rodriguez"
Four-month real-life response to Tezepelumab in patients with multi-failure to other biologics.
Allergol Immunopathol (Madr)
November 2024
To evaluate the response to Tezepelumab in real clinical practice, we performed an analysis of the clinical, functional, and inflammatory characteristics of 13 patients with severe asthma after completing four doses of Tezepelumab was performed. When comparing clinical parameters such as asthma control test (ACT), FENO value, exacerbations in the last 4 months, blood eosinophils and FEV1%, before receiving Tezepelumab and after four doses of Tezepelumab, statistically significant differences were found in ACT levels (p=0.0072), exacerbations (p=0.
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- The study investigates the genetic factors linked to severe COVID-19, specifically focusing on hospitalized cases in admixed Americans.
- Researchers conducted the largest genome-wide association study (GWAS) for COVID-19 hospitalization in this population, identifying four significant genetic associations, including two novel loci found in Latin Americans.
- The findings highlight the importance of including diverse populations in genomic research, aiming to improve understanding of genetic risks associated with COVID-19 across different ethnic groups.
Article Synopsis
- The hippocampus is significantly impacted by neuroinflammation in disorders like neurodegenerative diseases, and pleiotrophin (PTN) plays a critical role in managing this inflammation.
- Research involving lipopolysaccharide (LPS) treatment showed that varying levels of PTN affect acute and long-term neuroinflammation responses, including changes in TNF-α levels and neuronal progenitor cells in the hippocampus.
- Overexpression of PTN can enhance acute microglial reactions and inhibit long-term changes in neurogenesis and astrocytic responses related to inflammation, indicating the importance of PTN in the brain's inflammatory response.