Disorders of ventricular contractility and electrogenesis in the early stage of endotoxin shocked rabbits.

This is a report on ventricular contractility and electrogenesis disorders in rabbits, following intravenous injection of E. coli endotoxin at a dose of 2 mg.kg-1.

Location of the electrical center of ventricular depolarization in rabbits.

This is a study on the location of the ventricular depolarization center, carried out on fifteen healthy rabbits according to the method of Ritsema van Eck. It is established that the level of equivalent heart dipole coincides with the fourth or fifth intercostal space, but in some laboratory animals this level displays a lower positioning. The inference is reached that to secure correct application of Frank's lead system it is necessary to use a prompt and precision method for determination of the level in question in each individual case.

A study of ventricular electrogenesis and contractility in acute pressure overload of the right heart ventricle.

A model of fat embolism induced acute pressure overload of rabbit right ventricle of heart is presented. A decrease in right ventricular contractility is registered as early as the first minutes after loading. Changes in spatial magnitude and polar coordinates of vectors of ventricular depolarization, and myocardial ischemia manifestations are recorded.

[The effect of endotoxin on the cardiovascular system].

The dynamics of changes in myocardial contractility and pressure in the left ventricle of the heart and the femoral artery were studied in rabbits before and after intravenous infusion of 2 mg/kg endotoxin. The left ventricle was catheterized. The signal from the left-ventricular pressure transducer was fed into a microcomputer after analog-digital conversion for calculating the maximal rate of increase in intraventricular pressure.

Decreases in left ventricular contractility during endotoxin shock in rabbits.

The participation of the heart in shock syndrome formation during endotoxin shock is a problem still awaiting solution. The task undertaken is to assess the work of the left ventricle and arterial pressure in rabbits before and after endotoxin injection at a dose of 2 mg.kg-1.