Publications by authors named "R Logan"
Synthetic opioids like fentanyl are highly potent and prevalent in the illicit drug market, leading to tolerance, dependence, and opioid use disorder (OUD). Chronic opioid use disrupts sleep and circadian rhythms, which persist even during treatment and abstinence, increasing the risk of relapse. The body's molecular clock, regulated by transcriptional and translational feedback loops, controls various physiological processes, including the expression of endogenous opioids and their receptors.
View Article and Find Full Text PDFOpioid-use disorder (OUD) during pregnancy has increased in the United States to critical levels and is a leading cause of maternal morbidity and mortality. Untreated OUD is associated with pregnancy complications in particular, preterm birth. Medications for OUD, such as buprenorphine, are recommended with the added benefit that treatment during pregnancy increases treatment post-partum.
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- Ischemic stroke-associated pneumonia (iSAP) affects around 10% of stroke patients during their hospital stay, highlighting the need for better predictive tools as current scales are ineffective.
- This study analyzed 1,767 acute ischemic stroke patients to assess the predictive value of euthyroid sick syndrome (ESS) as a biomarker for iSAP, finding that older age and comorbidities like atrial fibrillation and COPD increase the risk.
- Results indicate that ESS is a significant predictor of iSAP, with a sensitivity of 35.64% and specificity of 87.92%, suggesting its potential use in identifying at-risk stroke patients early on.
Opioid use disorder (OUD) has emerged as a severe, ongoing public health emergency. Current, frontline addiction treatment strategies fail to produce lasting abstinence in most users. This underscores the lasting effects of chronic opioid exposure and emphasizes the need to understand the molecular mechanisms of drug seeking and taking, but also how those alterations persist through acute and protracted withdrawal.
View Article and Find Full Text PDFMalaria remains one of the highest causes of morbidity and mortality, with 249 million cases and over 608,000 deaths in 2022. Insecticides, which target the Anopheles mosquito vector, are the primary method to control malaria. The widespread nature of resistance to the most important insecticide class, the pyrethroids, threatens the control of this disease.
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