In this work, nanoemulsion-based delivery system was developed by encapsulation of fennel essential oil. A response surface methodology was used to study the influence of the processing conditions in order to obtain monomodal nanoemulsions of fennel essential oil using the microchannel homogenization technique. Results showed that it was possible to obtain nanoemulsions with very narrow monomodal distributions that were homogeneous over the whole observation period (three months) when the appropriate mechanical energy was supplied by microfluidization at 14 MPa and 12 passes.
View Article and Find Full Text PDFEach time the foot contacts the ground during running there is a rapid deceleration that results in a shock wave that is transmitted from the foot to the head. The fatigue of the musculoskeletal system during running may decrease the ability of the body to absorb those shock waves and increase the risk of injury. Insoles are commonly prescribed to prevent injuries, and both custom-made and prefabricated insoles have been observed to reduce shock accelerations during running.
View Article and Find Full Text PDFComput Methods Biomech Biomed Engin
January 2016
The electrocardiogram (ECG) is often acquired during magnetic resonance imaging (MRI), but its analysis is restricted by the presence of a strong artefact, called magnetohydrodynamic (MHD) effect. MHD effect is induced by the flow of electrically charged particles in the blood perpendicular to the static magnetic field, which creates a potential of the order of magnitude of the ECG and temporally coincident with the repolarisation period. In this study, a new MHD model is proposed by using MRI-based 4D blood flow measurements made across the aortic arch.
View Article and Find Full Text PDFComput Biol Med
March 2011
In this work we present a fixed point algorithm to extract the atrial rhythm in atrial tachyarrhythmias from the surface electrocardiogram (ECG). In the frequency domain the atrial signal is characterized by a concentration of power around a main peak in the bandwidth 3-10Hz. The proposed algorithm exploits this discriminative property of the atrial component in combination with the decoupling of the atrial and other components superposed in the ECG.
View Article and Find Full Text PDFObjectives: The extraction of the atrial activity in atrial fibrillation episodes is a must for clinical purposes. During atrial fibrillation arrhythmia, the independent atrial and ventricular signals are superposed in the electrocardiogram, fulfilling the independent component analysis (ICA) model. We propose three new algorithms that constrain the classical ICA solution to fit the spectral content of the atrial component.
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