Publications by authors named "R Lindblom"

Article Synopsis
  • The study investigates how internal thoracic artery (ITA) graft failure impacts the recurrence of symptoms after coronary artery bypass grafting (CABG) surgery.
  • Data was collected from 1997 to 2020 on patients who underwent CABG with a single-vessel ITA graft, tracking outcomes like deaths and angiography results.
  • Findings revealed that, after 20 years, only 16.4% of the patients had a failed ITA graft, suggesting that ongoing disease progression in the original coronary arteries is likely the primary cause of symptom recurrence rather than issues with the graft itself.
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Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPR) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPR remodels and restores damaged mitochondrial proteomes. Here, we have developed a functional proteomics framework, termed MitoPQ (Mitochondrial Proteostasis Quantification), to dissect the UPR's role in maintaining proteostasis during stress.

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Cargo sequestration is a fundamental step of selective autophagy in which cells generate a double-membrane structure termed an "autophagosome" on the surface of cargoes. NDP52, TAX1BP1, and p62 bind FIP200, which recruits the ULK1/2 complex to initiate autophagosome formation on cargoes. How OPTN initiates autophagosome formation during selective autophagy remains unknown despite its importance in neurodegeneration.

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Objectives: Coronary artery bypass grafting for advanced coronary artery disease is a well-established procedure with excellent long-term results. The issue of saphenous vein graft (SVG) performance and its relation to clinical symptoms and thereby the potential for improvement by using superior grafts are still not fully understood. We aim to estimate the contribution of late SVG failure to the long-term outcome.

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Article Synopsis
  • The study evaluates the outcomes of surgeries on the aortic arch and descending aorta for patients with aneurysms and dissections, focusing on neurological injuries and in-hospital mortality.
  • 34 patients were analyzed, with an 18% in-hospital mortality rate and a 67% incidence of neurological issues, including spinal cord injuries and strokes.
  • Predictors of negative outcomes include the need for postoperative dialysis and previous/current smoking, emphasizing their impacts on both in-hospital and overall mortality rates.
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