[From Hippocrates to Harvey: twenty centuries of research on circulation].

The concept of blood circulation was difficult to emerge. By assessing the non-religious cause of any disease, Hippocrates allowed future studies and observations to elucidate the concept of blood circulation. Alexandria's school erroneously described the roles of respiration and air transfer up to the viscera.

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.

[Cardiac metastasis from malignant melanoma].

The authors describe a case of cardiac metastasis associated with a malignant melanoma, which was removed in its totality. Malignant melanoma is a tumour which metastases frequently at the cardiac level. The mechanism of implantation and the symptomatology of this metastatic localisation are discussed.