Publications by authors named "R Lievin"
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm preferentially involving the upper aerodigestive tract. Here we show that NK-cell-specific Trp53 disruption in mice leads to the development of NK-cell lymphomas after long latency, which involve not only the hematopoietic system but also the salivary glands. Before tumor onset, Trp53 knockout causes extensive gene expression changes, resulting in immature NK-cell expansion, exclusively in the salivary glands.
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- Primary testicular lymphoma (PTL) is a rare form of diffuse large B-cell lymphoma (DLBCL), making up 1%-2% of DLBCL cases and is linked to poor outcomes due to high rates of central nervous system relapse.
- In a study of 15 patients (5 with PTL and 10 with DLBCL involving the testes), treatment with high-dose methotrexate and R-CHOP showed a 73% complete response (CR) rate overall, with 100% CR in PTL patients and only 55% in DLBCL-T patients.
- The molecular similarities between PTL and primary CNS lymphoma (PCNSL) indicate they may have common origins, highlighting
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- HIV infection increases the risk of diffuse large B-cell lymphoma (DLBCL), and this study analyzed B-cell activating cytokines and T cell subsets in 51 HIV-associated DLBCL patients undergoing R-CHOP treatment.
- R-CHOP therapy led to decreased IL-10 and fluctuating IL-6 levels while BAFF levels initially rose and then fell; a significant increase in naïve B cells was observed, but recovery of other B cell types was gradual.
- With a median follow-up of 41 months, 5-year progression-free survival was 61.8% and overall survival was 67.4%, with main causes of death being disease progression and sepsis, highlighting the need for assessing B-cell disturbances in patient
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. In this study, we performed a comprehensive genetic analysis of 178 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNA), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely, HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1.
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