[Not Available].

A focused point-of-care abdominal ultrasound is an examination performed at the patient's location and interpreted within the clinical context. This review gives an overview of this examination modality. The objective is to rapidly address predefined dichotomised questions about the presence of an abdominal aortic aneurysm, gallstones, cholecystitis, hydronephrosis, urinary retention, free intraperitoneal fluid, and small bowel obstruction.

Point-of-Care Lung Ultrasound in Emergency Medicine: A Scoping Review With an Interactive Database.

Background: This scoping review was conducted to provide an overview of the evidence of point-of-care lung ultrasound (LUS) in emergency medicine. By emphasizing clinical topics, time trends, study designs, and the scope of the primary outcomes, a map is provided for physicians and researchers to guide their future initiatives.

Research Question: Which study designs and primary outcomes are reported in published studies of LUS in emergency medicine?

Study Design And Methods: We performed a systematic search in the PubMed/MEDLINE, Embase, Web of Science, Scopus, and Cochrane Library databases for LUS studies published prior to May 13, 2023.

Antibiotic stewardship based on education: minor impact on knowledge, perception and attitude.

The purpose of this study was to implement an education-based antibiotic stewardship programme at two regional hospitals in Denmark, and thereby reduce consumption of antibiotics in general and cephalosporins and fluoroquinolones in particular. We aimed to improve physicians' knowledge, prescribing practices and perceptions and attitudes towards antibiotics, and to achieve changes in behaviour. The antibiotic stewardship programme comprised education, guidelines, audits and feedback and ward rounds by a clinical microbiologist.

Both Reactivity and Accessibility Are Important in Cytochrome P450 Metabolism: A Combined DFT and MD Study of Fenamic Acids in BM3 Mutants.

Cytochrome P450 102A1 from Bacillus megaterium (BM3) is a fatty acid hydroxylase that has one of the highest turnover rates of any mono-oxygenase. Recent studies have shown how mutants of BM3 can produce metabolites of known drug compounds similar to those observed in humans. Single-point mutations in the binding pocket change the regioselective metabolism of fenamic acids from aromatic hydroxylation to aliphatic hydroxylation.

The applicability of guidelines on antimicrobials provided by the Danish Health Authority.

Introduction: Our objective was to investigate the know-ledge of "Guidelines on prescribing antibiotics for physicians and others in Denmark" published by the Danish Health Au-thority in 2012, and the usefulness of these guidelines for Danish hospital doctors.

Methods: We collected information on the perceived aware-ness and usefulness of the guidelines using a ques-tionnaire distributed at two regional hospitals. Furthermore, to evaluate the use of the guidelines, we collected data about 310 patients treated with antimicrobials at the two hospitals.