Publications by authors named "R Lemoine"
Article Synopsis
- Neutrophil subsets with regulatory properties are often seen as harmful to immune responses against tumors and infections, but new findings suggest otherwise in cases of severe viral respiratory infections (VRI).
- A significant population of neutrophils expressing programmed death-ligand 1 (PD-L1) was identified in humans and mice with VRI, exhibiting strong regulatory functions but diminished antimicrobial capabilities.
- Depleting these PD-L1 neutrophils or blocking their function during VRI led to worse outcomes, indicating that they play a crucial role in managing inflammation and could be potential targets for future treatments.
In recent decades, the integration of horses (Equus ferus) in European rewilding initiatives has gained widespread popularity due to their potential for regulating vegetation and restoring natural ecosystems. However, employing horses in conservation efforts presents important challenges, which we here explore and discuss. These challenges encompass the lack of consensus on key terms inherent to conservation and rewilding, the entrenched culture and strong emotions associated with horses, low genetic diversity and high susceptibility to hereditary diseases in animals under human selection, as well as insufficient consideration for the social behaviour of horses in wild-living populations.
View Article and Find Full Text PDFBackground And Purpose: Gastrointestinal tumours overexpress voltage-gated calcium (Ca3) channels (Ca3.1, 3.2 and 3.
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- Agriculture faces challenges from global changes, especially drought, which limits crop production, evidenced in pea (Pisum sativum) during early reproductive phases.
- The study analyzed how a water deficit affected plant growth, sugar content, and gene expression at two key stages: embryonic and seed-filling.
- Results showed significant gene regulation related to water stress in the embryonic stage, indicating a shift in sugar metabolism, highlighting the importance of transcription factors and transporters during drought response and seed development.
The worldwide extinction of megafauna during the Late Pleistocene and Early Holocene is evident from the fossil record, with dominant theories suggesting a climate, human or combined impact cause. Consequently, two disparate scenarios are possible for the surviving megafauna during this time period - they could have declined due to similar pressures, or increased in population size due to reductions in competition or other biotic pressures. We therefore infer population histories of 139 extant megafauna species using genomic data which reveal population declines in 91% of species throughout the Quaternary period, with larger species experiencing the strongest decreases.
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