Publications by authors named "R Lehloenya"
Introduction: Cutaneous immune-mediated adverse drug reactions are more prevalent in people with human immunodeficiency virus (PWH). Severe cutaneous adverse drug reactions (SCAR) are a life-threatening subset of cutaneous adverse drug reactions (CADRs) and a significant public health issue in settings endemic for human immunodeficiency virus and tuberculosis. However, limited data are available on CADR requiring hospitalisation in African settings.
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- Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe skin reactions to drugs, involving immune system responses from CD8 T cells.
- Researchers analyzed skin and blister fluid from 15 SJS/TEN patients using various sequencing techniques, revealing 15 distinct cell types and noting active immune responses in affected areas.
- Key findings indicate that certain T cell receptors and inflammatory markers in skin tissues could be targeted for new treatments, highlighting the role of keratinocytes and T cells in the disease's progression.
Background: RegiSCAR validation criteria for drug reaction with eosinophilia and systemic symptoms (DRESS) includes lymphadenopathy, a frequent feature of both tuberculosis (TB) and human immunodeficiency virus (HIV). TB is the most common HIV-associated coinfection. Advanced HIV is associated with lymph node (LN) fibrosis.
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