[The place of therapeutic education in the care of an HIV-positive patient].

Since the advent of triple therapy, HIV has become a chronic disease. Therapeutic patient education (TPE) seems to have a place in this accompaniment, which has sometimes lasted several decades. The role of a nurse in TPE is still essential for the accompaniment of an HIV positive patient.

[Care and information for an HIV-positive patient].

Since the year 2000, AIDS has become a chronic disease that can be treated and monitored. The two specific and necessary parameters for monitoring patients are the CD4 lymphocyte rate, which indicates the state of the immune system, and the viral load, which makes it possible to monitor the effectiveness of the antiretroviral treatments prescribed; in addition, blood antiretroviral drugs can be measured in certain cases. Today, it is clear that a patient who is effectively treated with an undetectable viral load is no longer a contaminant and that he or she will live with the disease, while facing the health issues common to everyone: emotional life, aging, other pathologies.

Structural and ultrastructural analysis of gills and gut of Hexagenia rigida nymphs (ephemeroptera) in relation to contamination mechanisms.

In the context of an experimental approach to organic and inorganic mercury bio-accumulation by burrowing mayfly nymphs-Hexagenia rigida-, gills and different parts of the gut were investigated by light and electron microscopes. In the gut, two regions were studied: (1) mesenteron (midgut) characterized by cells with microvilli and a peritrophic membrane throughout this part, a lot of fungal hyphae being found on it; (2) proctodeum (hindgut) characterized by macrovilli, the apical face of cells being covered by a thick layer of chitin; many bacteria were observed at the bottom of macrovilli. The stomodeum (foregut) is extremely short.

Eccentric localization of von Willebrand factor in an internal structure of platelet alpha-granule resembling that of Weibel-Palade bodies.

Immunogold staining was used to study the ultrastructural distribution of von Willebrand factor (vWF) in unstimulated platelets. vWF was detected in the alpha-granules with a specific eccentric distribution pattern opposite the nucleoids. Similar findings were obtained with a polyclonal antibody or a pool of monoclonal antibodies to human vWF.

[Effect of flurbiprofen and acetylsalicylic acid on the ultrastructure of blood platelets].

Flurbiprofene or acetylsalicylic acid did not change the structure of inactivated platelets. With flurbiprofene 50% aggregation inhibition was obtained at 10(-6) to 10(-5) M concentrations. To obtain the same result with acetylsalicylic acid, 10(-4) to 10(-3) M concentrations were necessary.