Publications by authors named "R Lauppe"
Background: The real-world treatment and outcomes of patients with anaplastic lymphoma kinase positive (ALK+) advanced non-small cell lung cancer treated with ALK Tyrosine Kinase Inhibitor (TKI) drugs in Sweden is not well described.
Material And Methods: A retrospective population-based cohort study was conducted using Swedish national registers. All patients with a filled prescription for an ALK TKI between January 2012 and October 2020 were included.
Aims: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive condition caused by deposition of transthyretin amyloid fibrils in the heart and is associated with poor quality of life and a shortened lifespan. This study aimed to describe the prevalence, clinical characteristics, and mortality of patients with ATTR-CM, using multiple national health registers in Denmark, Finland, Norway, and Sweden.
Methods And Results: Transthyretin amyloid cardiomyopathy patients were identified during 2008-2018 using a combination of diagnosis codes for amyloidosis and heart disease and were matched to patients with non-ATTR heart failure (HF).
Article Synopsis
- - The study aims to compare healthcare resource use for patients with transthyretin amyloid cardiomyopathy (ATTR-CM) to those with heart failure (HF) in Denmark, Finland, Norway, and Sweden between 2008 and 2018.
- - Researchers analyzed data from nationwide health registers, finding that ATTR-CM patients had significantly higher hospital visits and admissions both before and after diagnosis compared to HF patients.
- - Results indicate that ATTR-CM results in a greater healthcare burden, with about double the outpatient visits and 50% more hospitalizations in the year following diagnosis compared to HF patients, highlighting the need for studies on earlier diagnosis and treatment to potentially reduce these healthcare demands.
Objective: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a rare, progressive and fatal condition caused by deposition of transthyretin amyloid fibrils in the heart. This study aims to identify all patients diagnosed with ATTR-CM in Sweden, estimate the prevalence of ATTR-CM, describe patient characteristics and mortality, assess the importance of early symptoms (red flags) for identification of ATTR-CM, and compare with patients with heart failure (HF).
Methods: This retrospective study combined multiple national health registers covering all specialist visits and prescriptions for the entire population of Sweden.
Background: Secondary hyperparathyroidism (SHPT) is a common and major complication in chronic kidney disease (CKD), reflecting the increase of parathyroid hormone (PTH) in response to reduced vitamin D signalling and hypocalcaemia. This meta-analysis evaluated the impact of nutritional vitamin D (NVD) (cholecalciferol or ergocalciferol) on SHPT-related biomarkers.
Methods: A systematic literature search was performed in PubMed to identify relevant randomized control trials to be included in the meta-analysis.