Publications by authors named "R Larcher"
Introduction: The increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria.
Methods: This retrospective multicentre study investigated the real-world use of FDC in 114 immunocompromised adults treated for MDR infections in 12 French hospitals (June 2020-November 2023).
First case report of a vertebral osteomyelitis caused by carbapenem-resistant treated with imipenem/cilastatin/relebactam prolonged infusion then meropenem/vaborbactam in continuous infusion.
Front Pharmacol
October 2024
Article Synopsis
- Bone and joint infections (BJIs) from multidrug-resistant bacteria, like carbapenem-resistant Enterobacterales, are rising, highlighting the need for new treatment options.
- Novel β-lactam/β-lactamase inhibitors, specifically imipenem/cilastatin/relebactam (I-R) and meropenem/vaborbactam (MVB), lack sufficient data on their effectiveness for BJIs, particularly with prolonged infusions.
- A case study showed successful treatment of vertebral osteomyelitis using extended and continuous infusions of I-R and MVB, suggesting these methods could be effective against BJIs caused by resistant bacteria.
Article Synopsis
- The study aimed to analyze the characteristics and outcomes of critically ill patients with severe pneumonia caused by SARS-CoV-2 across different pandemic waves, focusing on morbidity and mortality predictors.
- Conducted from March 2020 to October 2021, the study included 437 adult patients and found that ICU mortality decreased from 26% in the first wave to around 10% in later waves, with factors like age and comorbidities influencing death risk.
- The research concluded that overall survival improved due to the effects of interventions like vaccination and dexamethasone, although bronchopulmonary aspergillosis increased mortality risk significantly to 36%.
Hydric stress is a leading cause of atypical aging (ATA) in wine, characterized by unpleasant olfactory notes. The main sensorial and chemical marker of ATA is 2-aminoacetophenone (AAP). Early detection of ATA before the second fermentation in sparkling wines (SWs) is crucial for producing high-quality products.
View Article and Find Full Text PDFThe Maillard reaction (MR) involves interactions between reducing sugars and amino acids or proteins during heating, producing Maillard reaction products (MRPs) that influence food flavour, aroma, and colour. Some MRPs exhibit antioxidant properties, prompting interest in their potential as natural food preservatives. This study aimed to develop a method for detecting and identifying antioxidant MRPs using high-pressure liquid chromatography (HPLC) coupled with high-resolution mass spectrometry (HRMS).
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