Publications by authors named "R Lampe"
Novel Porcine Model Reveals Two Distinct LGR5 Cell Types During Lung Development and Homeostasis.
Am J Respir Cell Mol Biol
November 2024
Article Synopsis
- Cells expressing LGR5 are crucial for homeostasis and regeneration in various organs, but their function in the human lung has not been well studied, especially compared to findings from mouse models.
- Utilizing a new transgenic pig model, researchers identified two significant populations of LGR5 cells in the lung that are similar to those found in humans but not in mice.
- The study reveals that LGR5 expression occurs transiently in fetal lung progenitor cells and is absent in postnatal lungs but can be reactivated in specific organoid models, highlighting the complex roles of LGR5 cells in lung development and potential for repair.
Intraventricular hemorrhage (IVH)4 is one of the most threatening neurological complications associated with preterm birth which can lead to long-term sequela such as cerebral palsy. Early recognition of IVH risk may prevent its occurrence and/or reduce its severity. Using multivariate logistic regression analysis, risk factors significantly associated with IVH were identified and integrated into risk scales.
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- A 13-year-old male neutered domestic shorthair cat exhibited behavioral changes and neurological issues linked to the forebrain, leading to a veterinary examination.
- Advanced brain imaging revealed two extra-axial masses and a significant amount of subdural fluid accumulation.
- Histological analysis confirmed the masses as multiple meningiomas and the subdural fluid as cerebrospinal fluid, marking a unique presentation of concurrent feline meningiomas and fluid accumulation not previously documented.
Unlabelled: Hyperandrogenism is a determining diagnostic factor for PCOS. If pregnancy is conceived, it is considered high-risk due to several potential complications, but the correlation between pre-pregnancy androgen levels and obstetric outcomes is poorly characterized.
Objective: To determine if pre-pregnancy serum androgen concentrations and androgen indexes differed when certain obstetric and neonatal outcomes appeared in PCOS.
Infertility affects an estimated 40-50% of women with polycystic ovary syndrome (PCOS), the leading cause of anovulatory infertility, but only a small proportion of the patients require in vitro fertilization (IVF) therapy. Both PCOS and IVF are associated with an increased risk of obstetric complications. To compare preconception endocrine profiles and symptoms, as well as obstetric outcomes of PCOS patients who achieved successful pregnancies with and without IVF treatment.
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