(Adenine Phosphoribosyltransferase) Mutation in Laboratory-Selected Vancomycin-Intermediate .

Comparative genomic sequencing of laboratory-derived vancomycin-intermediate (VISA) (MM66-3 and MM66-4) revealed unique mutations in both MM66-3 (in and ), and MM66-4 (in and ), compared to hetero-VISA parent strain MM66. Transcriptional profiling revealed that both MM66 VISA shared 79 upregulated genes and eight downregulated genes. Of these, 30.

Effect of Echinostoma caproni on Presumptive Lactic Acid Bacteria Abundance and Salmonella enterica Serovar Typhimurium Colonization in the Mouse Gut.

Co-infections of mammalian hosts with intestinal helminths and bacterial pathogens are common, especially in areas with inadequate sanitation. Interactions between co-infecting species and host microbiota can cause significant changes in host immunity, disease severity, and pathogen transmission, requiring unique treatment for each case. A greater understanding of the influences of parasite-bacteria co-infections will improve diagnosis and therapeutic approaches to control infectious diseases.

Bacteria on the Soles of Patient-Issued Nonskid Slipper Socks: An Overlooked Pathogen Spread Threat?

Background: This is the first study to determine whether nonskid slipper socks in contact with the hospital floor and worn into bed contaminate bed linen.

Purpose: The main purpose of the study was to determine whether contamination of hospital linen occurred with bacteria transferred from the soles of nonskid slipper socks that have touched the floor.

Methods: This study mimicked real patients walking on a hospital floor wearing slipper socks and getting back into bed with the slipper socks on.

Host hydrogen rather than that produced by the pathogen is important for Salmonella enterica serovar Typhimurium virulence.

Salmonella enterica serovar Typhimurium utilizes molecular hydrogen as a substrate in various respiratory pathways, via H2-uptake enzymes termed Hya, Hyb, and Hyd. A different hydrogenase, the hydrogen-evolving Hyc enzyme, removes excess reductant during fermentative growth. Virulence phenotypes conferred by mutations in hyc genes, either alone or in combination with mutations in the H2-uptake enzyme genes, are addressed.

Draft Genome Sequences of Vancomycin-Susceptible Staphylococcus aureus Related to Heterogeneous Vancomycin-Intermediate S. aureus.

We report the draft genome sequences of three vancomycin-susceptible methicillin-resistant Staphylococcus aureus strains. S. aureus strain MV8 is a sequence type 8 (ST-8) staphylococcal cassette chromosome mec element type IV (SCCmec IV) derivative, while the other two strains (S.