Publications by authors named "R L van Zyl"
Purpose: Posterior tibial slope (PTS) influences knee kinetics and kinematics. The purpose of this study was to investigate morphology and variation within a sample of the black and white male and female population.
Method: 480 randomly selected lateral knee radiographs were included.
Malaria, caused by parasitic protozoans of the Plasmodium genus, continues to be one of the greatest global health crises, especially in Africa. The emergence of antimalarial drug resistance continues to be a health problem necessitating an urgent need for alternative and cost-effective antimalarials. Using a molecular hybridization approach, we report the design and synthesis of an efficacious novel class of antiprotozoal agents; (E)-1-(4-(4,6-diphenylpyrimidin-2-yl)piperazin-1-yl)-3-phenyl prop-2-en-1-one derivatives (8a-r).
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- The SERENA-2 trial investigates the efficacy of camizestrant, a new oral selective estrogen receptor degrader, compared to the traditional injectable SERD, fulvestrant, in treating advanced hormone receptor-positive breast cancer in post-menopausal women.
- This phase 2 trial includes patients who have experienced disease progression after previous endocrine therapies and assesses different dosages of camizestrant against fulvestrant, focusing on progression-free survival rates as the primary outcome.
- Conducted across 74 centers worldwide, the study also monitors the safety and side effects of the treatments among all participants who received at least one dose.
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- The study aimed to explore the safety and accessibility of direct posterior arthroscopy portals in the knee using cadaveric specimens.
- Of 95 formalin-embalmed and 9 fresh-frozen knees tested, the risk of neurovascular damage was found to be 9.6%, primarily associated with the lateral cannula.
- While the medial portal was generally safe, the lateral portal posed significant risks, particularly affecting the common fibular nerve, making its use not recommended at this time.
Malaria is still a complex and lethal parasitic infectious disease, despite the availability of effective antimalarial drugs. Resistance of malaria parasites to current treatments necessitates new antimalarials targeting proteins. The present study reported the design and synthesis of a series of a 2-(4-substituted piperazin-1-yl)--(5-((naphthalen-2-yloxy)methyl)-1,3,4-thiadiazol-2-yl)acetamide hybrids for the inhibition of dihydrofolate reductase (DHFR) using computational biology tools followed by chemical synthesis, structural characterization, and functional analysis.
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