Publications by authors named "R L van Linschoten"
Predicting mucosal inflammation in IBD patients using patient-reported symptom scores and a faecal calprotectin home test: protocol for a multicentre prospective validation study.
Laura Janssen Reinier Cornelis Anthonius van Linschoten Rachel Louise West Lennard P L Gilissen Mariëlle Romberg-Camps
BMJ Open
October 2024
Introduction: Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) with a relapsing-remitting nature. With adequate non-invasive prediction of mucosal inflammation, endoscopies can be prevented and treatment optimised earlier for better disease control. We aim to validate and recalibrate commonly used patient-reported symptom scores combined with a faecal calprotectin (FC) home test as non-invasive diagnostic tool for remote monitoring of IBD, both in daily practice and in a strict trial setting.
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- Sport-induced injuries, like stress fractures, often affect young, active individuals, particularly runners during intense training or competitions.
- Stress fractures, especially of the femoral neck, can be hard to diagnose due to the patient's age and overall good health, requiring careful monitoring of subtle symptoms.
- A case of a 30-year-old male runner, who developed a complete femoral neck fracture post-marathon, highlights the need for timely intervention to avoid complications and ensure a better recovery outcome.
Dutch multidisciplinary guideline on anterior knee pain: Patellofemoral pain and patellar tendinopathy.
Knee Surg Sports Traumatol Arthrosc
July 2024
Article Synopsis
- The study aimed to create a comprehensive guideline for managing patellofemoral pain (PFP) and patellar tendinopathy (PT) to aid healthcare professionals in making clinical decisions.
- An expert panel assessed existing literature using the GRADE method to evaluate the strength of treatment recommendations, focusing on exercise therapy as the main treatment approach.
- Key recommendations include starting with exercise therapy, using additional treatments only if necessary, limiting pain medications, and reserving surgery for specific cases, while acknowledging the low certainty of evidence for these strategies.
Article Synopsis
- A study examined variations in treatment outcomes and costs of inflammatory bowel disease (IBD) across 8 hospitals in the Netherlands, focusing on how these differences can inform quality and cost improvements in care.
- The study included 1010 patients and found that while clinicians reported high remission rates (83%), patient-reported rates were significantly lower (40%), indicating discrepancies in perceived outcomes.
- Most variations in treatment outcomes and costs were linked to individual patient factors rather than the hospitals themselves, suggesting that future efforts should concentrate on enhancing patient-level care rather than evaluating hospitals based on these variations.
Article Synopsis
- In the LADI trial, researchers found that extending adalimumab (ADA) dosing intervals was just as effective as standard dosing for Crohn's disease patients in remission.
- The study aimed to create a prediction model to identify patients who could successfully increase their dosing intervals based on trial data.
- Results showed that 60.6% of patients successfully extended their dosing, with certain factors (like smoking and prior surgeries) making success less likely; the model's effectiveness needs further external validation before clinical use.