Publications by authors named "R L ZuWallack"

Background: Since comorbid conditions are frequently present in chronic obstructive pulmonary disease (COPD) and affect outcome, a composite scoring system to quantify comorbidity might be helpful in assessing mortality risk.

Methods: We tested the hypothesis that the Charlson Comorbidity Index (CCI) score at the time of an outpatient medical clinic encounter for COPD predicts all-cause mortality. Cox Proportional Hazards analyses were used in 200 randomly selected patients to relate CCI scores to all-cause mortality out to 5 years.

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Background: The term "Overlap Syndrome" (OS) describes the presence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in a single individual. Excessive daytime sleepiness (EDS) is a common symptom of OS shown to be associated with an increased risk of cardiovascular disease (CVD) that could be reduced through exercise. Thus, we propose to investigate a novel exercise intervention in individuals with the EDS-OS phenotype as they are at highest risk of CVD yet have the greatest barriers to exercise.

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Article Synopsis
  • Cardiovascular disease is a major health issue for patients with Overlap Syndrome, which involves both Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease.
  • A study was conducted to evaluate endothelial function in 7 patients with Overlap Syndrome on CPAP therapy, focusing on the relationship between flow-mediated dilation (FMD) and physical activity levels.
  • Results indicated a strong correlation between increased physical activity and better endothelial function, suggesting that FMD could help identify high-risk patients who may benefit from more exercise; however, larger studies are necessary for validation.
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Random-digit dialing (RDD) telephone surveys are challenged by declining response rates and increasing costs. Many surveys that were traditionally conducted via telephone are seeking cost-effective alternatives, such as address-based sampling (ABS) with self-administered web or mail questionnaires. At a fraction of the cost of both telephone and ABS surveys, opt-in web panels are an attractive alternative.

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