Latent Variable Analysis of Demographic and Clinical Drivers of Care Intensity Before Palliative Care Consultation Among Older Adult Patients with Traumatic Brain Injury.

Background: Traumatic brain injury (TBI) is a significant cause of morbidity and mortality in the older adult population, and palliative care consultation can assist in goals-of-care discussions. However, patterns of hospital care delivered before consultation are understudied for older adult patients with TBI. The objective of this study was to identify demographic and clinical drivers of preconsultation care intensity in this population.

Combined Analysis of the Leaf Metabolome, Lipidome, and Candidate Gene Function: Insights into Genotypic Variation in Phosphorus Utilization Efficiency in .

Stylo () exhibits excellent tolerance to low-phosphate (Pi) availability, but the underlying mechanisms responsible for improving the phosphorus (P) utilization efficiency (PUE) remain unclear. This study employed metabolomics, lipidomics, and gene expression analyses to investigate the differential responses to low-Pi stress between the high-PUE genotype CF047827 and the cultivar Reyan No. 2.

Multicomponent Synthesis of Alkyl BCP-Heteroaryls via Electron Donor-Acceptor Complex Photoactivation under Mild Conditions.

In the vanguard of sustainable chemistry, the pursuit of efficient pathways for the synthesis of alkyl bicyclo[1.1.1]pentane-heteroaryls has captured the attention of the scientific vanguard.

The hidden weavers: A review of DNA/RNA R-loops in stem cell biology and therapeutic potential.

R-loops, three-stranded nucleic acid structures composed of RNA-DNA hybrids, are increasingly recognized as central regulators of genomic stability and transcription. These structures play critical roles across various cellular processes, including DNA replication, repair, and gene regulation, with significant implications for stem cell biology and disease pathogenesis. This review comprehensively explores the molecular underpinnings of R-loop formation, emphasizing the dual nature of R-loops in both facilitating normal cellular functions and contributing to genomic instability.

Baculovirus protein kinase 1 activates AMPK-protein phosphatase 5 axis to hijack transcription factor EB for self-proliferation.

Baculovirus causes lethal nuclear polyhedrosis in insects, whereas its regulatory mechanism on host transcription has not been fully illustrated. Herein, Bombyx mori nucleopolyhedrovirus (BmNPV) infection caused dephosphorylation and thus cytoplasmic-nucleo translocation of transcription factor EB (BmTFEB) by inhibiting Mechanistic target of rapamycin complex 1 (MTORC1), while upregulating Adenosine monophosphate-activated protein kinase (AMPK) signaling to promote self-proliferation through the rival protein kinase 1 in Bombyx mori. Significantly, B.