Publications by authors named "R L Woolley"
Identifying the composition of large vesicles in the cytoplasm of oocytes.
Reprod Fertil Dev
December 2024
Context Oocyte vesicles, or vacuoles, have been described using transmission electron microscopy in most species. In sheep and cow oocytes, vesicles constitute up to 30% of the cytoplasm, their volume decreases during maturation and is lower in poorer quality oocytes, suggesting they are important for oocyte competence. However, the composition and function of these organelles is unknown.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to compare the effectiveness of ultrasound (US) elastography-guided fine-needle aspiration cytology (FNAC) versus conventional US-guided FNAC in diagnosing thyroid nodules, focusing on reducing nondiagnostic results.
- - Conducted across 18 hospitals in England, the trial involved 982 participants who were randomized to either the elastography (493 patients) or conventional method (489 patients), finding no significant differences in the nondiagnostic rates or time to diagnosis between the two methods.
- - The results showed similar rates of malignancy and benign findings in both groups, indicating that US elastography-guided FNAC may not provide additional benefits compared to standard US-guided FNAC for thyroid nodules. *
Article Synopsis
- People with Parkinson's disease often have speech problems, affecting how they talk and interact with others.
- The PD COMM trial tested two types of therapy to help with these speech issues: one is called Lee Silverman Voice Treatment LOUD, and the other is regular speech therapy from the National Health Service.
- The study took place in the UK and involved different groups of participants, comparing the effectiveness and cost of each therapy method against doing nothing.
Introduction: ElaTION is a large multi-centre pragmatic randomised controlled trial, performed in 18 secondary/tertiary hospitals across England, comparing elastography ultrasound-guided fine needle aspiration cytology (EUS-FNAC) with ultrasound-guided FNAC (US-FNAC) alone in the diagnostic assessment of thyroid nodules. Secondary trial outcomes, reported here, assessed the accuracy of ultrasound-alone (US) compared with US-guided FNAC to inform and update current practice guidelines.
Methods: Adults with single or multiple thyroid nodules who had not undergone previous FNAC were eligible.
Background: Strain and shear wave elastography which is commonly used with concurrent real-time imaging known as real-time ultrasound shear/strain wave elastography is a new diagnostic technique that has been reported to be useful in the diagnosis of nodules in several organs. There is conflicting evidence regarding its benefit over ultrasound-guided fine-needle aspiration cytology alone in thyroid nodules.
Objectives: To determine if ultrasound strain and shear wave elastography in conjunction with fine-needle aspiration cytology will reduce the number of patients who have a non-diagnostic first fine-needle aspiration cytology results as compared to conventional ultrasound-only guided fine-needle aspiration cytology.