Publications by authors named "R L Wickremasinghe"

Introduction: Models derived from non-Sri Lankan cohorts are used for cardiovascular (CV) risk stratification of Sri Lankans.

Objective: To develop a CV risk prediction model using machine learning (ML) based on data from a Sri Lankan cohort followed up for 10 years, and to compare the predictions with WHO risk charts.

Design: Cohort study.

View Article and Find Full Text PDF
Article Synopsis
  • Strongyloidiasis is a neglected tropical disease that poses significant risks to immunosuppressed individuals, yet it hasn't been thoroughly researched in Sri Lanka.
  • This study involved immunocompromised patients, using various diagnostic methods, including fecal microscopy, molecular PCR, and serology to detect the parasite Strongyloides stercoralis.
  • Results showed low detection rates for strongyloidiasis; only one fecal sample tested positive through traditional cultures, while PCR and ELISA revealed 11.4% and 16.4% positivity, respectively, indicating a need for improved diagnostic methods.
View Article and Find Full Text PDF

Diabetes mellitus is a significant contributor to the disease burden in Sri Lanka. Despite government efforts to improve access to care for those with chronic illness, major gaps remain. We assessed the prevalence and correlates of unmet needs among persons with diabetes mellitus type 2 to inform policies on improving healthcare access in a predominantly tax-funded public healthcare system.

View Article and Find Full Text PDF

Background: Health policies form the foundation for provisioning best level care and are important for all stakeholders including patients and healthcare providers. Health policy analysis and evaluation allows policy makers to improve an existing policy, terminate a non-effective policy and to successfully implement future policies.The objective was to assess the coherence between the two local policy documents on NCD prevention and control in Sri Lanka, the national NCD policy (NCD policy) and the multisectoral action plan (MSAP), and to assess the consistency of MSAP with the global action plan for NCDs.

View Article and Find Full Text PDF

Background: Localized cutaneous leishmaniasis (LCL) is a chronic ulcerating disease. A literature review identified inconsistencies in clinical trials. The aims of this study were to reach a consensus on the most important domains to measure when assessing LCL, agree on parameters to measure the domains, and develop a tool representing a Core Outcome Set (COS), for use in clinical assessment of LCL.

View Article and Find Full Text PDF