Collagen fibrillogenesis in situ: fibril segments become long fibrils as the developing tendon matures.

Tissue architecture, stability, and mechanical attributes are all determined by the structure and organization of collagen fibrils. Therefore, the characterization of fibril growth steps and determination of how this growth is regulated is essential to the elucidation of how tissues are assembled. We have proposed that fibril segments are intermediates in the formation of mature fibrils.

A network-based prototype for interactive telemedicine & automated management of distributed, clinical databases.

A network-based prototype has been developed to automate the process of generating and maintaining distributed databases of medical images and clinical reports, and for conducting interactive consultation among disparate clinical and research sites irrespective of the architecture of interacting computers. Pathologists routinely interpret gross and microscopic specimens to tender diagnoses and to engage in a broad spectrum of research. This assessment process leads to clinical decisions often limited by time constraints and by the availability of local expertise.

The role for regional autopsy centers in the evaluation of covered deaths. Survey of opinions of US and Canadian chairs of pathology and major health insurers in the United States.

Objective: To evaluate the advantages and disadvantages of, as well as the attitudes of health care professionals and insurers toward, the development of regional autopsy services.

Design: Survey of 150 medical school departments of pathology in the United States and Canada and 12 representative major health insurers in the United States.

Results: Of the 25 respondents from the pathology departments, most were in favor of regionalization of autopsy services, if properly underwritten.