Publications by authors named "R L Spears"
Introduction: Despite progress in research and technological advancements, the delivery of oral health care continues to be plagued by disparities in accessibility and affordability. Dental caries and periodontal disease remain major issues, and new challenges such as socioeconomic disparities and emerging public health dangers also contribute to the complexity of the issue. To address these challenges, dental education and oral healthcare delivery must shift their focus from disease treatment to disease prevention and health promotion.
View Article and Find Full Text PDFNickel-based catalysts are widely studied for water-gas shift (WGS), a key intermediate step in hydrogen production from carbon-based feedstocks. Their viability under practical conditions is limited at high temperatures when Ni aggregates and converts CO to methane, an undesirable side product. Because experimental and computational studies identify undercoordinated Ni step sites as most active toward CH formation, we eliminate Ni step sites by atomically dispersing Ni into networked, nanoparticulate CeO aerogels.
View Article and Find Full Text PDFArticle Synopsis
- Protein modification has gained importance in chemical biology, especially for creating more uniform bioconjugates, with a focus on modifying antibodies through cysteine targeting.
- Current methods typically react all accessible cysteines in the same way after reducing disulfide bonds, limiting site-selective modifications.
- The research introduces innovative dehydroalanine forming reagents capable of selectively modifying different cysteines in antibodies and small peptides, allowing for more precise antibody modifications and the potential to expand chemical biology tools.