Publications by authors named "R L Smoot"
Article Synopsis
- This study investigates the expression and location of fibroblast activation protein (FAP) in various liver tumors, focusing on cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), hepatocellular adenoma (HCA), and focal nodular hyperplasia (FNH).
- FAP immunostaining results showed that a high percentage of CCA exhibited moderate to strong FAP expression compared to other tumor types, indicating a significant distinction.
- The findings suggest that FAP is consistently present in CCA tumor stroma regardless of clinical features, highlighting its potential as a target for future diagnostic and therapeutic strategies in treating different CCA subtypes.
Article Synopsis
- Surgical resection is a primary treatment for pancreas ductal adenocarcinoma (PDAC), but patient outcomes vary due to social determinants of health (SDH), particularly influenced by the area deprivation index (ADI).
- A study analyzing 1,001 PDAC patients revealed that those from more marginalized backgrounds (higher ADI) were 1.57 times more likely to lose follow-up care after surgery compared to less marginalized individuals.
- The findings highlight the need to address SDH to improve care continuity for marginalized patients, suggesting that future efforts should focus on reducing the barriers they face in accessing healthcare.
Article Synopsis
- A study was conducted on 628 patients who underwent pancreatoduodenectomy (PD) for pancreatic cancer to analyze long-term reoperation rates and reasons for these surgeries.
- Results showed that 30% of patients required any additional surgery within 5 years, and 21.2% had reoperations related to the initial PD, most commonly due to cancer recurrence and incisional hernias.
- The findings indicate that while a significant number of patients experienced further surgeries, the specific rates for serious complications were relatively low.
Background: Cystic neuroendocrine tumor liver metastases (NETLM) are rare and dynamics in the liquid compartment often misinterpreted as rapid progression, affecting selection for liver resection candidates. This study retrospectively evaluates surgical and oncologic outcomes in patients with cystic versus solid NETLM from small bowel and pancreatic primaries.
Methods: Between 2000 and 2020, 12 patients with cystic NETLM were identified among 464 patients who underwent >90 % tumor cytoreduction debulking hepatectomy at the Mayo Clinic.
Cholangiocarcinoma (CCA) is a highly aggressive form of liver cancer and is an increasing cause of cancer-related death worldwide. Despite its increasing incidence globally and alarming mortality, treatment options for CCA have largely remained unchanged, stressing the importance of developing new effective therapies. YAP activation is common in CCA, and its major transcriptional signaling partners are the TEAD proteins.
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