Publications by authors named "R L Ribeiro Tinoco"
Article Synopsis
- - Vulvar diseases, including lichen sclerosus (LS), significantly impact women's quality of life, causing both physical discomfort and psychological issues, yet they remain understudied.
- - This research employs advanced techniques like single-cell and spatial transcriptomics to compare vulvar skin from patients with lichen sclerosus to healthy individuals, revealing key cellular and molecular changes associated with the disease.
- - Findings indicate that VLS involves cellular stress in skin cells, enhanced immune activity, and disrupted signaling pathways, suggesting potential biomarkers and therapeutic targets that could inform future treatments.
Oyster populations within the Chesapeake Bay have been drastically reduced over the last century mainly due to unregulated human activities and diseases. Regulations and restoration efforts have focused on restoring oyster populations while also considering their ability to provide ecosystem services, such as coastal protection and water quality improvement, among others. To promote oyster growth and the settlement of new populations, a recent technique adopted along the east coast of the US is the use of oyster castles (OCs).
View Article and Find Full Text PDFPurpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, though uncertainty exists regarding their immune-related safety. The objective of this study was to assess the comparative safety profile (odds ratio) of ICIs and estimate the absolute rate of immune-related serious adverse events (irSAEs) in cancer patients undergoing treatment with ICIs.
Methods: We searched for randomized trials till February 2021, including all ICIs for all cancers.
Article Synopsis
- Chronic infections and cancers cause T cell exhaustion, leading to challenges in the immune response against these conditions.
- The study identifies HMGB2 as a critical protein that supports the differentiation and maintenance of exhausted CD8 T cells, specifically stem-like progenitor T cells (Tpex) during persistent viral infections and tumors.
- HMGB2's role suggests it could be a potential target for future T cell-based immunotherapies, highlighting its importance in improving immune responses.