Clinical Impact of Contouring Variability for Prostate Cancer Tumor Boost.

Purpose: The focal radiation therapy (RT) boost technique was shown in a phase III randomized controlled trial (RCT) to improve prostate cancer outcomes without increasing toxicity. This technique relies on the accurate delineation of prostate tumors on MRI. A recent prospective study evaluated radiation oncologists' accuracy when asked to delineate prostate tumors on MRI and demonstrated high variability in tumor contours.

Comparing brass mesh to tissue equivalent bolus materials for volumetric modulated arc therapy chest wall irradiation.

Purpose: To compare the superficial dose when using brass mesh bolus (BMB), no bolus, or 3 mm tissue-equivalent bolus with a pseudo-flash volumetric modulated arc therapy (VMAT) breast treatment planning technique.

Methods: Two different beam arrangements for right-sided irradiation and one beam arrangement for bilateral irradiation were planned on an inhomogeneous thorax phantom in accordance with our clinical practice for VMAT postmastectomy radiotherapy (PMRT). Plans were optimized using pseudo-flash and representative critical organ optimization structures were used to shape the dose.

Specific Absorbed Fractions for Spontaneous Fission Neutron Emitters in the ICRP Reference Pediatric Voxel Phantom Series.

Specific absorbed fractions (SAFs) are key components in the workflow of internal exposure assessment following the intake of a radionuclide, allowing quick conversion of particle energy released in a source region to the expected absorbed dose in target regions throughout the body. For data completeness, SAFs for spontaneous fission neutron emitters are currently needed for the recently adopted ICRP reference pediatric voxel phantom series. With 77 source regions within each reference individual and 28 radionuclides decaying via spontaneous fission, full Monte Carlo simulation requires significant computation time.

Assessing the performance of an automated breast treatment planning software.

Purpose: To assess the dosimetric performance of an automated breast planning software.

Methods: We retrospectively reviewed 15 breast cancer patients treated with tangent fields according to the RTOG 1005 protocol and 30 patients treated off-protocol. Planning with electronic compensators (eComps) via manual, iterative fluence editing was compared to an automated planning program called EZFluence (EZF) (Radformation, Inc.

Benchmarking failure mode and effects analysis of electronic brachytherapy with data from incident learning systems.

Purpose: Failure modes and effects analysis (FMEA) is a prospective risk assessment tool for identifying failure modes in equipment or processes and informing the design of quality control systems. This work aims to benchmark the performance of FMEAs for electronic brachytherapy (eBT) of the skin and for breast by comparing predicted versus actual failure modes reported in multiple incident learning systems (ILS).

Methods And Materials: Two public and our institution's internal ILS were queried for Xoft Axxent eBT-related events over 9 years.