Publications by authors named "R L Malek"
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults, characterized by resistance to conventional therapies and poor survival. Ferroptosis, a form of regulated cell death driven by lipid peroxidation, has recently emerged as a promising therapeutic target for GBM treatment. However, there are currently no non-invasive imaging techniques to monitor the engagement of pro-ferroptotic compounds with their respective targets, or to monitor the efficacy of ferroptosis-based therapies.
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- A biocompatible polyelectrolyte complex (PEC) was created using Tragacanth gum (TG) and chitosan (CS) to explore its potential biological applications, with an optimized TG:CS ratio of 18:2 identified through various tests.
- The study found that at pH 4, TG and CS showed strong interactions, highlighting charge neutralization in the PECs, which featured a unique macroporous structure.
- The PEC cryogel demonstrated significant antibacterial activity against E. coli and S. aureus, while also promoting wound healing in human fibroblast cells without any toxic effects.
Background: Recent advances in stroke care have led to improvements in survival and rates of stroke recurrence. However, there is a lack of data on trends of major vascular events, and risk factors associated with non-fatal and fatal outcomes. We aim to identify demographical and clinical factors leading to incidence of subsequent major vascular events after the first-ever stroke.
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- Metformin has been a staple in treating type 2 diabetes for years and is also used off-label for conditions like gestational diabetes and polycystic ovarian syndrome due to its insulin-sensitizing properties.
- In 2022, it became the only oral medication approved by the European Union for managing diabetes during pregnancy, showing safety and benefits for mothers while crossing the placenta to the baby.
- Benefits for mothers include reduced weight gain and lower risk of pre-eclampsia; however, long-term effects on their children are still uncertain, necessitating further research on potential concerns like small-for-gestational-age (SGA) outcomes.