Publications by authors named "R L Magness"
Article Synopsis
- VEGFR2 is crucial for directing blood vessel formation in the placenta, and a study identified proteins MDMX and PICALM as key partners in its function.
- Immunological methods showed the presence of several receptors, including the oxytocin receptor, in cells associated with angiogenesis and placenta function, suggesting novel pathways for fetal communication.
- The research indicated a link between certain protein levels and pregnancy complications like preeclampsia, as well as differences in protein expressions among various delivery methods, highlighting potential implications for maternal and neonatal health.
Context: Enhanced levels of catecholestradiols, 2-hydroxyestradiol (2-OHE2) or 4-hydroxyestradiol (4-OHE2), are reported in endometriosis. During gestation, catecholestradiol activation of adrenergic receptors (AR) elevates estrogen receptor (ER)-independent proliferation of uterine arterial endothelial cells.
Objective: To investigate β-AR-mediated catecholestradiol effects on human endometrial stromal cell (HESC) and epithelial cell survival in endometriosis.
Normal pregnancy is associated with dramatic increases in uterine blood flow to facilitate the bidirectional maternal-fetal exchanges of respiratory gases and to provide sole nutrient support for fetal growth and survival. The mechanism(s) underlying pregnancy-associated uterine vasodilation remain incompletely understood, but this is associated with elevated estrogens, which stimulate specific estrogen receptor (ER)-dependent vasodilator production in the uterine artery (UA). The classical ERs (ERα and ERβ) and the plasma-bound G protein-coupled ER (GPR30/GPER) are expressed in UA endothelial cells and smooth muscle cells, mediating the vasodilatory effects of estrogens through genomic and/or nongenomic pathways that are likely epigenetically modified.
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