Publications by authors named "R L M Bekkers"
Colposcopy referrals and CIN3 detection after triage by host cell DNA methylation and/or HPV genotyping in HPV positive women with low-grade cytology from a population-based Dutch primary HPV screening trial.
Int J Cancer
December 2024
High-risk HPV (hrHPV)-based screening has led to many unnecessary colposcopy referrals, mainly because of direct referral after low-grade cytology (ASC-US/LSIL). DNA methylation and genotyping tests on ASC-US/LSIL samples have the potential to significantly improve the efficiency of screening. In this study, 12 triage strategies were constructed from FAM19A4/miR124-2 or ASCL1/LHX8 methylation, HPV16/18 or HPV16/18/31/33/45 genotyping and 1-year repeat cytology.
View Article and Find Full Text PDF: Advances in treatment options have barely improved the prognosis of ovarian carcinoma (OC) in recent decades. The inherent heterogeneity of OC underlies challenges in treatment (development) and patient stratification. One hurdle for effective drug development is the lack of patient-representative disease models available for preclinical drug research.
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- * It compares outcomes of large loop excision (LLETZ), cold-knife conization (CKC), and hysterectomy in a cohort of 4,243 patients, finding that LLETZ had a higher recurrence rate of high-grade dysplasia compared to CKC.
- * When a complete radical excision is achieved, both LLETZ and CKC show similar low rates of recurrence, while hysterectomy results in no cases of cervical dysplasia or cancer, suggesting conservative treatments can be
Article Synopsis
- In the FIGO 2018 classification, women with early-stage cervical cancer are now classified differently based on their tumor's size and spread, which could change how they are treated.
- A study looked at a group of 992 women with specific types of cervical cancer to see how often the cancer spread to lymph nodes (pN+) and found that certain factors like lymphovascular space invasion (LVSI) increased the risk of spread.
- The results suggest that women with LVSI-positive tumors should have lymph node checks, but those with LVSI-negative tumors may not need this if their tumor size and other factors are considered.
Effects of a combined exercise and dietary intervention on clinical outcomes in patients with ovarian cancer: the Physical Activity and Dietary intervention in OVArian cancer (PADOVA) randomized controlled trial.
Int J Gynecol Cancer
September 2024
Objective: Chemotherapy treatment modifications can impact survival in patients with ovarian cancer, particularly when the relative dose intensity falls below 85%. Exercise and dietary interventions may benefit treatment tolerability. This study aimed to explore the effects of a combined exercise and dietary intervention on secondary outcomes of the Physical Activity and Dietary intervention in OVArian cancer (PADOVA) trial, specifically relative dose intensity and progression-free survival.
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