Publications by authors named "R L Kruse"
Article Synopsis
- The study aimed to find protein signatures in blood that could help identify individuals at high risk for inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis.
- Researchers analyzed blood samples from a large population, utilizing machine-learning methods to identify and validate these protein signatures across multiple cohorts.
- A specific combination of 29 proteins was effective in differentiating preclinical CD cases from controls, achieving a high accuracy, while the prediction for ulcerative colitis was less robust but still significant.
Article Synopsis
- A cohort study evaluated the effectiveness of platelet-poor plasma (PPP) injections for treating acute hamstring strains in male collegiate football players aged around 20 years.
- The study included 20 patients who received PPP injections and found that they returned to full sports participation after an average of 29.4 days, with pain improvement noticeable as early as two weeks post-injection.
- The results suggest PPP is a safe treatment option that may help speed up recovery from hamstring injuries, with no recurrent injuries reported within a year.
Decline in mitochondrial function is linked to decreased muscle mass and strength in conditions like sarcopenia and type 2 diabetes. Despite therapeutic opportunities, there is limited and equivocal data regarding molecular cues controlling muscle mitochondrial plasticity. Here we uncovered that the mitochondrial mRNA-stabilizing protein SLIRP, in complex with LRPPRC, is a PGC-1α target that regulates mitochondrial structure, respiration, and mtDNA-encoded-mRNA pools in skeletal muscle.
View Article and Find Full Text PDFBackground: Recent genetic and transcriptomic data highlight the need for improved molecular characterisation of inflammatory bowel disease (IBD). Proteomics may advance the delineation of IBD phenotypes since it accounts for post-transcriptional modifications.
Aim: We aimed to assess the IBD spectrum based on inflammatory serum proteins and identify discriminative patterns of underlying biological subtypes across multiple European cohorts.