Publications by authors named "R L Kosinsky"
Cells expressing features of senescence, including upregulation of p21 and p16, appear transiently following tissue injury, yet the properties of these cells or how they contrast with age-induced senescent cells remains unclear. Here, we used skeletal injury as a model and identified the rapid appearance following fracture of p21+ cells expressing senescence markers, mainly as osteochondroprogenitors (OCHs) and neutrophils. Targeted genetic clearance of p21+ cells suppressed senescence-associated signatures within the fracture callus and accelerated fracture healing.
View Article and Find Full Text PDFPeptidyl arginine deiminases (PADIs) catalyze protein citrullination, a post-translational conversion of arginine to citrulline. The most widely expressed member of this family, PADI2, regulates cellular processes that impact several diseases. We hypothesized that we could gain new insights into PADI2 function through a systematic evolutionary and structural analysis.
View Article and Find Full Text PDFCells expressing features of senescence, including upregulation of p21 and p16, appear transiently following tissue injury, yet the properties of these cells or how they contrast with age-induced senescent cells remains unclear. Here, we used skeletal injury as a model and identified the rapid appearance following fracture of p21+ cells expressing senescence markers, mainly as osteochondroprogenitors (OCHs) and neutrophils. Targeted genetic clearance of p21+ cells suppressed senescence-associated signatures within the fracture callus and accelerated fracture healing.
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- This study explores how regulatory T cells (Tregs) behave in inflammatory bowel diseases like Crohn's disease, focusing on their metabolic processes that impact gut homeostasis.
- Researchers used various advanced techniques (like electron microscopy and mass cytometry) to analyze Tregs' cellular structures and functions in humans and murine models of colitis.
- Key findings show that inhibiting a specific protein (VDAC1) disrupts Treg metabolism and increases sensitivity to inflammation, while manipulating metabolic pathways can restore proper Treg function and potentially inform new therapeutic strategies for inflammatory diseases.
Background & Aims: The incidence of Crohn's disease (CD) continues to increase worldwide. The contribution of CD4 cell populations remains to be elucidated. We aimed to provide an in-depth transcriptional assessment of CD4 T cells driving chronic inflammation in CD.
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