CCL2/CCR2 Signalling in Mesenchymal Stem/Progenitor Cell Recruitment and Fracture Healing in Mice.

Macrophage efferocytosis (clearance of apoptotic cells) is crucial for tissue homeostasis and wound repair, where macrophages secrete factors that promote resolution of inflammation and regenerative signalling. This study examined the role of efferocytic macrophage-associated CCL2 secretion, its influence on mesenchymal stem/progenitor cell (MSPC) chemotaxis, and in vivo cell recruitment using Ccr2 (KO) mice with disrupted CCL2 receptor signalling in two regenerative models: ossicle implants and ulnar stress fractures. Single cell RNA sequencing and PCR validation indicated that efferocytosis of various apoptotic cells at bone injury sites (osteoblasts, pre-osteoblasts, MSPC) upregulated CCL2.

Understanding spatio-temporal complexity of vegetation using drones, what could we improve?

Unraveling the intricate spatial and temporal complexities of vegetation represents a crucial key to understanding ecosystem functioning. Drones, as cutting-edge technology, hold immense potential in bridging the gap between on-ground measurements and satellite remote sensing data. Nonetheless, a multitude of challenges still looms, with one of the foremost being the nuanced identification of scales that strike a balance between capturing maximum complexity while minimizing measurement errors.

Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues.

The mechanical function of the myocardium is defined by cardiomyocyte contractility and the biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an important unmet challenge due to limitations in existing approaches for engineering myocardial tissue. Here, they established arrays of cardiac microtissues with tunable mechanics and architecture by integrating ECM-mimetic synthetic, fiber matrices, and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), enabling real-time contractility readouts, in-depth structural assessment, and tissue-specific computational modeling.

(In) visibility of health and illness: Instagram as an unregulated public health platform.

This paper examines the changing terrain of accessing health and illness guidance and information through the lens of social media, specifically It argues how Instagram, has increasingly become an unregulated -public health platform in today's digital society. Drawing on extensive empirical interview data from two research projects before and during the COVID-19 pandemic, which explored how users showcased and performed health and illness on Instagram, this paper demonstrates how Instagram has became an important forum from which to perform proactive health practices, as well as to legitimate ill health through making healthy behaviours visible, as well as invisible illnesses like disease, COVID-19, and mental health conditions. Over time and through continuous sharing of this content may contribute to increased understanding or even a de-stigmatisation of such illnesses or chronic conditions.