Publications by authors named "R L JASPER"
Local adaptation can cause both peaks and troughs in nucleotide diversity within populations.
G3 (Bethesda)
November 2024
Article Synopsis
- Local adaptation can have varying effects on nucleotide diversity within populations, sometimes causing reductions and other times increases, depending on factors like migration and selection strength.
- The study examines genome-wide patterns of nucleotide diversity influenced by local adaptation and finds that low migration leads to more significant diversity depletion, while high migration results in peaks of diversity over smaller genomic distances.
- The research highlights the complexity of local adaptation's influence on nucleotide diversity, indicating that there isn't a one-size-fits-all pattern, making it challenging to use nucleotide diversity as a universal marker for local adaptation.
Background: Weightbearing cone-beam computed tomography (WBCT) has proven useful for analysis of structural changes of the foot and ankle when compared to conventional radiographs. WBCT allows for extraction of distance and coverage mapping metrics, which may provide novel insight into hallux rigidus (HR). This study retrospectively assessed HR joint space using distance and coverage mapping in a case-control study.
View Article and Find Full Text PDFTarso-metatarsal joints and naviculocuneiform joints comprising midfoot is the second most commonly involved joints following the first metatarsophalangeal joint in the foot. However, related factors of midfoot arthritis (MA) have been rarely reported. The bony structure and alignment can be more precisely assessed using Weight-Bearing Computed Tomography (WBCT) than conventional radiographs.
View Article and Find Full Text PDFBackground And Aims: Substance use among persons with Crohn's disease (CD) is associated with symptomatic exacerbation and poorer quality of life. However, data on the prevalence of substance use among individuals with CD are limited. Therefore, our study aimed to estimate the burden of alcohol and drug use among individuals with incident CD in the United States.
View Article and Find Full Text PDFArticle Synopsis
- Patient and Public Involvement (PPI) is increasingly recognized as important in clinical trials but is challenging in basic science; the UK Coronavirus Immunology Consortium (UK-CIC) successfully included PPI in its research on COVID-19’s immune response.
- Key factors for success included securing funding for a PPI panel, providing expert administrative support, and fostering strong relationships between public contributors and researchers, enabling diverse perspectives to influence research direction.
- The UK-CIC demonstrates that meaningful PPI in basic immunology research is feasible, establishing a model that should be expanded for future research, highlighting the potential impact of PPI in laboratory settings.