Publications by authors named "R L Hodes"
Article Synopsis
- The article emphasizes the NIH's efforts to enhance women's health through innovative policies and research, expanding beyond reproductive health to encompass all aspects of women's health.
- The NIH has identified unique ways that diseases affect women due to biological and social factors, leading to significant scientific advances, but noted that access to these advancements is still a challenge for many women.
- Recent initiatives aim to bridge these gaps by promoting integrative women's health research, ultimately benefiting the health of women across all stages of life.
Article Synopsis
- * The study reveals that most ATM-deficient T-LBL cultures have various genomic alterations in the PTEN gene, resulting in the absence of functional PTEN protein and constant activation of AKT signaling.
- * These lymphomas are sensitive to the AKT inhibitor MK-2206, indicating they rely on pAKT signaling for survival, and this loss of PTEN expression and activation of AKT is not seen in non-cancerous thymocytes.
The tumor suppressor p53 antagonizes tumorigenesis, notably including the suppression of T cell lymphomas while its role on physiological T cell biology including thymic T cell development has not been fully understood. Invariant natural killer T (iNKT) cells develop in the thymus as innate-like αβ-T cells which consist of NKT1, NKT2 and NKT17 subsets. We found that the tumor suppressor p53 regulates specifically thymic NKT17 development.
View Article and Find Full Text PDFAcross social structures within society, including healthcare, power relations manifest according to gender, socioeconomic status, race, ethnicity, and class influencing infection related healthcare access and health providing-behaviours. Therefore, accounting for sociocultural drivers, including gender, race, and class, and their influence on economic status can improve healthcare access and health-providing behaviours in infection prevention and control (IPC) as well as antibiotic use, which in turn helps mitigate the spread of antimicrobial resistance (AMR). This Wellcome funded research will investigate how and why the social determinants of health and economic status influence how people seek, experience, and provide healthcare for suspected or proven (bacterial) infections and how these factors influence antibiotic prescribing and use in South Africa (upper middle-income country) and India (lower middle-income country).
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